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Promethazine Hydrochloride Injection BP is indicated for the following conditions: Treatment of allergic reactions such as: uncomplicated allergic conditions of the immediate type, e.g., pruritus, urticaria and angioedema, when oral therapy is impossible or contraindicated.
™ Promethazine Hydrochloride Injection BP is indicated for the following conditions: Treatment of allergic reactions such as:
1.uncomplicated allergic conditions of the immediate type, e.g., pruritus, urticaria and angioedema, when oral therapy is impossible or contraindicated. Treatment and prevention of vomiting including:
2.motion sickness;
3.drug induced nausea;
4. prevention and control of nausea and vomiting associated with certain types of anaesthesia and surgery, such as procedures with a high incidence of post-operative vomiting (e.g., 1.gynaecological surgery, strabismus or middle ear surgery, and electroconvulsive therapy); in patients with a past history of motion sickness or postoperative vomiting; and in patients in whom avoidance of vomiting is crucial (e.g., neurosurgery and eye surgery). Page 2 of 10 Promethazine has sedative effects and it is also used in:
5. pre-operative, post-operative and obstetric (during labour) sedation.
| Posology and method of administration | IM,IV |
| PH | 5.0-6.0 |
Allergic conditions Adults: 25 mg to 50 mg by deep intramuscular injection or slow intravenous injection; may be repeated within two hours if necessary. Maximum dose up to 150 mg daily. Antiemetic Antiemetics should not be used in vomiting of unknown etiology in children and adolescents (see section 4.4 Special Warnings and Precautions for Use). In established nausea or vomiting due to causes other than motion sickness: Adults: 12.5 to 25 mg, by intramuscular or intravenous injection, every four hours as needed. Children: 5 to 12 yrs old - 12.5 mg by intramuscular injection. Sedative/hypnotic Adults: 25 to 50 mg by intramuscular or intravenous injection. Children: When oral route is not possible; 2 to 5 yrs old - 7.5 to 10 mg by intramuscular injection. 6 to 10 yrs old - 10 to 12.5 mg by intramuscular injection. Pre-operative and post-operative sedation Adults: 25 to 50 mg by intramuscular or intravenous injection, usually with pethidine and atropine.
