Audited Supplier
Internal Medicine
For oral administration
Elderly, Children, Adult
Solid
Tablet
Plant Extract
Natural Product Extraction
Available
Available
Cool and Dry Place
36 Months
B.P./USP
5000 Boxes
Available
Antimalarial
OEM
Box/Carton
20mg+120mg/40mg+240mg/80mg+480mg
China
3004601000
Product Description
Product name: Artemether+Lumefantrine Tablets
PACKING:
| Artemether 20mg + Lumefantrine 120mg | 24tablets/blister/box |
| Artemether 20mg + Lumefantrine 120mg | 6tabletsX 4blisters/box |
| Artemether 40mg+ Lumefantrine 240mg | 6tabletsX 2blisters/box |
| Artemether 80mg + Lumefantrine 480mg | 6tablets/blister/box |
Pharmacodynamics
The combination of artemether and lumefantrine is used to treat certain kinds of malaria infections (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death). Artemether and lumefantrine should not be used to prevent malaria. Artemether and lumefantrine is in a class of medications called antimalarials. It works by killing the organisms that cause malaria.
Pharmacokinetics:
Orally administered Artemether is rapidly absorbed reaching therapeutic levels within 60-90 minutes. Artemether is metabolized in the liver to the demethylated derivate dihydroartemisinin (DHA). The elimination is rapid, with a T 1/2 of 2-4 hours. Dihydroartemisinin, being a potent antimalarial itself, has a T 1/2 of 2-4 hours. The degree of binding to plasma proteins varies markedly according to the species studied. The binding of Artemether with plasma protein in man is about 50%. Radioactivity distribution of Artemether was found to be equal between cells and plasma.
The absorption of Lumefantrine is highly influenced by lipids and food intake (from 10% by fasting to 100% at normal diet). Therefore patients should be encouraged to take the medication with some fatty food as soon as it can be tolerated.
Lumefantrine is N-debutylated in human liver microsomes . This metabolite has 5 to 8 fold higher antiparasitic effects than lumefantrine. Lumefantrine is found to be highly protein bound (95%). The elimination half life in malarial attaint patients will be 4 to 6 days. Lumefantrine and its metabolites are found in bile and faeces.
How should this medicine be used?
The combination of artemether and lumefantrine comes as a tablet to take by mouth. It is usually taken twice a day for 3 days as instructed by your doctor. Always take artemether and lumefantrine with food. If you are not able to eat, contact your doctor. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take artemether and lumefantrine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
| Weight(kg) | Tables/Dose(n) | Total Tablets(n) |
| 5-15 | 1 | 6 |
| 15-25 | 2 | 12 |
| 25-35 | 3 | 18 |
| ≥35 | 4 | 24 |
CAUTION!
Artemether and lumefantrine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache
- dizziness
- weakness
- muscle or joint pain
- tiredness
- difficulty falling asleep or staying asleep
- vomiting
- loss of appetite
- fever
- chill
