Factory Supply Isrib (trans-isoMer) CAS 1597403-47-8 as Brain Health Supplements

Product Name: ISRIB (trans-Isomer)
CAS Number: 1597403-47-8
Appearance: White Powder
Purity: 99%

Product Description:

ISRIB (trans-isomer) is a highly selective inhibitor of PERK (PKR-like endoplasmic reticulum kinase), with an IC50 of 5 nM. It is a promising compound for research into cellular stress responses, memory enhancement, and therapeutic applications targeting unfolded protein response (UPR) pathways.

Biological Activity:

• Mechanism:
  • ISRIB inhibits PERK signaling by suppressing eIF2α phosphorylation and its downstream effects, including ATF4 expression, without significantly affecting XBP1s mRNA splicing or XBP1s protein expression.
  • It targets the Integrated Stress Response (ISR) by modulating translation and stress granule assembly.
• Key Metrics:
  • Target: PERK (IC50 = 5 nM in a cell-free assay).

In Vitro Studies:

• ISRIB effectively inhibits endogenous ATF4 expression, reducing cellular survival rates under endoplasmic reticulum (ER) stress.
• Maintains XBP1s mRNA and protein levels, indicating selective inhibition of the PERK pathway.

In Vivo Studies:

• ISRIB exhibits favorable pharmacokinetic properties and good bioavailability in vivo.
• Animal Model: Mice injected intraperitoneally (0.25 mg/kg).
• Results:
  • Enhances spatial and fear memory, improving long-term memory formation.
  • Demonstrates potential in modulating cognitive functions and stress response pathways.

Applications:

1. Neuroscience Research: Enhances memory and studies cellular responses to ER stress.
2. Molecular Biology: Investigates the Integrated Stress Response (ISR) and unfolded protein response (UPR).
3. Drug Development: Serves as a tool for developing PERK-related therapeutics.

Features:

• High Selectivity: Specifically inhibits PERK with minimal off-target effects.
• Versatile Research Uses: Applicable in memory studies, stress pathway modulation, and therapeutic development.
• Potent Activity: Demonstrates efficacy at nanomolar concentrations.

Storage Information:

• Conditions: Store at 2-8°C in a sealed container. Protect from moisture and air to maintain product stability.

Safety and Handling:

• This product is intended for research purposes only. Not for human or veterinary use.

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