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Fluralaner 99% Pure Pharmaceutical Grade for Veterinary Use

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Zhejiang Multinpharma Co., Ltd.

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Zhejiang, China
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Model NO.:

Fluralaner

Fluralaner Raw Materials:

Fluralaner for Insect Control

Fluralaner Insect Repellent Ingredients:

Insect Repellent Fluralaner

Insect Repellent Chemical Fluralaner:

Fluralaner Insecticide Supplier

Trademark:

MT

Transport Package:

PE Bag, Foil Aluminum Bag, Cardboard Drum

Specification:

50g/100g/1kg/10kg/100kgs/1000kgs

Origin:

China

HS Code:

2937290090

Product Description

Insect Repellent Fluralaner chemical for Dog ,CAT animal with Best Price

Product Description

Common Name	Fluralaner
CAS Number	864731-61-3	Molecular Weight	556.28500
Density	N/A	Boiling Point	N/A
Molecular Formula	C₂₂H₁₇Cl₂F₆N₃O₃	Melting Point	N/A
MSDS	N/A	Flash Point	N/A

Fluralaner Biological Activity

Description	Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
In Vitro	Fluralaner potently inhibits flea reproduction capacity in vitro. Oviposition ceases completely at concentrations as low as 25.0 ng/mL. While no ovicidal effect is observed, fluralaner exerts a larvicidal effect at exceptionally low concentrations (6.25 ng/mL)[1].
In Vivo	In the simulated flea-infested home environment, flea-control efficacy on fluralaner-treated dogs is >99% at every time point measured for 12 weeks. No adverse events are observed in fluralaner-treated dogs. Fluralaner completely controls egg laying, larval development and flea reproduction even at sub-insecticidal concentrations. Oral treatment of dogs with fluralaner is highly effective for eliminating fleas in a simulated flea-infested home environment[1]. After single oral administration of Bravecto chewable tablets, mite numbers in skin scrapings are reduced by 99.8% on Day 28 and by 100% on Days 56 and 84. A marked decrease is observed in the occurrence of erythematous patches, crusts, casts and scales in the dogs treated with Bravectco[2].
Animal Admin	Dogs: Thirty-two (16 male and 16 female) healthy 8-week old Beagle dogs weighing 2.0 - 3.6 kg at first administration are included in the study. Fluralaner is administered on three occasions at 8-week intervals at doses of up to 56, 168, and 280 mg fluralaner/kg body weight, equivalent to 1, 3, and 5 times the highest recommended treatment dose of fluralaner; sham dosed dogs served as controls[2].
References	[1]. Williams H, et al. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in asimulated home environment. Parasit Vectors. 2014 Jun 19;7:275. [2]. Walther FM, et al. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-/-) Collies after oral administration. Parasit Vectors. 2014 Mar 6;7:86.