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Trade Name: Thymosin A 1
CAS NO.:62304-98-7
Purity: >98.0%
Molecular Formula:C129H215N33O55
Molecular Weight: 3108.28g/mol
Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
Appearance: White Lyophilized powder
Reconstitution: Required
Storage: After reconstitution store at 2°C - 8°C
WHAT IS Thymosin Alpha 1?
Thymosin alpha 1 (Tα1) is a powerful modulator of immunity and inflammation. Thymosin is a synthetic version of a naturally occurring hormone that circulates inside your thymus. Thymosin alpha-1 is an injectable synthetic hormone that is being studied for hepatitis B, lung and neck cancer, and as an immune-modulator in AIDS.
Thymalfasin (thymosin-alpha 1) is an immunomodulating agent able to enhance the Thl immune response. In vitro: conjugation of thymalfasin (Tα1) with iRGD preserves the immunomodulatory activity of the drug by increasing the proliferation of mouse spleen lymphocytes. Further, compared with Tα1 treatment, Tα1-iRGD treatment of MCF-7 cells considerably increases the number of cells undergoing apoptosis, resulting in a dose-dependent inhibition of cancer cell growth. [1] In vivo: Thymalfasin has been shown to have efficacy in multiple experimental models of immune dysfunction, mainly, infectious diseases such as hepatitis (woodchuck) and influenza (mouse), and cancer such as melanoma (mouse) and colorectal carcinoma (rat) where thymalfasin has shown antitumor effects.
Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.
Epithalon Benefits:
- Antibacterial and antifungal properties
- Increased vaccine effectiveness
- Suppression of tumor growth
- Help in eradicating the unhealthy cells to stop infection or cancer growth
- Strengthening your immune system
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