Audited Supplier
AWI
151533-22-1
C20h23can7o6
N/a
Tin
Normal
6 Months-12 Months
Amino Acid
Calcium L-5-Methyltetrahydrofolate
USP
0.5 Kg Tin
White to Light Yellow Crystalline Powder
AWI
1kg Bags/25kg Carton or as Client's Demand
China
Product Description
| Product Name | Calcium L-5-Methyltetrahydrofolate | ||
| Batch Number | 20190802 | Quantity | 5kgs |
| Quality Standard | USP | Packing | 0.5 kg/tin |
| Manufacture Date | 2019.07.25 | Expiry Date | 2021.07.24 |
Application and Uses
L-5-MTHF-Ca (5-mthf) is a naturally occurring salt-forming methyl derivative of folic acid. 5-mthf is also known as levomethyl-folate, which is the most biologically active and functional of folic acid. Form, more easily absorbed than ordinary folic acid. Common folic acid must be converted to type 1 methyl folate to participate in two major metabolic pathways: methylation and DNA synthesis, the only form of free folate normally present in human plasma and cells is 5-mthf. Lack of folic acid is usually caused by vitamin deficiency, which is insufficient for absorption.
Application:
1. Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.
2. as adjuvant therapy for colon cancer, rectal cancer
3. Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
2. as adjuvant therapy for colon cancer, rectal cancer
3. Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
| Item | Standard | Test Result | |
| Appearance | White to light yellow crystalline powder | Conforms | |
| Specific rotation (on anhydrous substance) | [α]25D(C=1.5% in water) | +40.6° | |
| Identification | HNMR | HNMR should be identical with that of reference | Conforms |
| HPLC | The retention time of the major peak in the chromatogram of Assay preparation corresponds to that in the chromatogram of the standard preparation,as obtained in the Assay | Conforms | |
| Calcium content (on anhydrous substance) | 7.0%~8.5% | 7.7% | |
| D-5-Methylfolate | ≤1.0% | Undetected | |
| (HPLC) Related compounds | Dimethyltetrahydrofolic acid | ≤0.15% | 0.07% |
| Single Impurity | ≤1.0% | 0.23% | |
| Total Impurity | ≤2.5% | 0.94% | |
| Residual solvent | Ethanol | NMT 5000ppm | Undetected |
| Water | ≤16.0% | 14.7% | |
| Chloride(CI) | ≤0.5% | Conforms | |
| Arsenic(As) | ≤1ppm | <1ppm | |
| Boron | ≤20ppm | Conforms | |
| Heavy Metals | NMT 20ppm Pb NMT 1ppm Cd NMT 0.5ppm As NMT 1.5ppm Hg NMT 1.5 ppm | Conforms | |
| Total Plate Count | ≤100cfu/g | Conforms | |
| Yeast & Mold | ≤100cfu/g | No detected | |
| Salmonella | Negative | No detected | |
| E.Coli | Negative | No detected | |
| Purity | >97.5% | 99.1% | |
| Conclusion | This batch of product complies to the standard. | ||
AWI Service
1. Supply high quality products with a reasonable price.
2. Keep shipment in time, provide complete customers clearance documents as customs request.
3. Provide agile and safe payments.
4. We will responsible for all quality issue.
5. Share marketing informations with customers update price in time.
2. Keep shipment in time, provide complete customers clearance documents as customs request.
3. Provide agile and safe payments.
4. We will responsible for all quality issue.
5. Share marketing informations with customers update price in time.
FAQ
1. What's your payment terms?
T/T, D/P, L/C, O/A
2. What's your delivery time?
Usually we will arrange the shipment within 14 days.
3. How about the packing?
Usually with 25 kg bag/carton/drum.
4. How about the validity of the products?
Usually 2 or 3 years.
5. What documents you provide?
Usually, Commerical Invoice, Packing List, Country of Origin, Insurance Policy, Bill of loading, COA , Health certificate.
6. What is loading port?
Usually, Qingdao, Tianjin and Shanghai
T/T, D/P, L/C, O/A
2. What's your delivery time?
Usually we will arrange the shipment within 14 days.
3. How about the packing?
Usually with 25 kg bag/carton/drum.
4. How about the validity of the products?
Usually 2 or 3 years.
5. What documents you provide?
Usually, Commerical Invoice, Packing List, Country of Origin, Insurance Policy, Bill of loading, COA , Health certificate.
6. What is loading port?
Usually, Qingdao, Tianjin and Shanghai
Amy Xu
High-Tech Industry Development Zone,Hefei,China
Welcome meet us at:
Fi Africa 15-17 March 2020 at Cairo Egypt. AWI Booth # H1.D46.
Fi Vietnam 1-3 July 2020 at HCMC Vietnam. AWI Booth # A1.112.
High-Tech Industry Development Zone,Hefei,China
Welcome meet us at:
Fi Africa 15-17 March 2020 at Cairo Egypt. AWI Booth # H1.D46.
Fi Vietnam 1-3 July 2020 at HCMC Vietnam. AWI Booth # A1.112.
