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PF-04965842 CAS 1622902-68-4 Abrocitinib Raw Materials Abrocitinib

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Xi'an Qiushi Co., Ltd.

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Shaanxi, China
Sun (Mr.)

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Model NO.:

QS-Abrocitinib

CAS No.:

1622902-68-4

Formula:

C14h21n5o2s

EINECS:

N-M

Packaging Material:

Negotiable

Storage Method:

Normal

Shelf Life:

>12 Months

Nutrient Composition:

Abrocitinib

Resource:

Abrocitinib

The content of active substances:

>99%

Product Name:

Abrocitinib

Name:

PF-04965842(Abrocitinib)

Appearance:

White Powder

Colour:

White

Pka:

10.55&Plusmn

Grade:

Pharmaceutical Grader

Assay:

>99%

Application:

Pharmaceutica

Specific:

COA

Test Method:

HPLC

Complexity:

474

Mf:

C14h21n5o2s

MW:

323.42

Density:

1.36

Psa:

99.4

Trademark:

QS-Abrocitinib

Transport Package:

Negotiable

Specification:

>99%

Origin:

Xi`an

Product Description

PF-04965842 CAS 1622902-68-4 Abrocitinib Raw Materials Abrocitinib

Product name	Abrocitinib
Cas number	1622902-68-4
Appearance	White powder
MF	C14H21N5O2S
MW	323.42

Abrocitinib (PF-04965842, PF04965842), Also known as Abrotinib, it is an orally administered JAK1 selective inhibitor with an IC50 of 29 nM, which can be used for autoimmune diseases. The overexpression and mutation of JAK1 are closely related to the occurrence and development of tumors. The IC50 values of Abrotinib on JAK2/3 and TYK2 were 803 nM and> 10 μ M and 1.253 μ M.

PF-04965842 (Abrotinib) has achieved positive results in multiple phase 3 clinical trials targeting patients with moderate to severe atopic dermatitis. It has shown statistically significant improvements in skin symptom clearance rate and disease severity, and rapidly improves itching symptoms in patients compared to placebo.