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The endogenous fatty acid palmitoylethanolamide (PEA) is one of the members of N-acyl-ethanolamines family. PEA was identified more than five decades ago and was shown to reduce allergic reactions and inflammation in animals along with influenza symptoms in humans. Interest in this compound faded, however, until the discovery that one of its structural analogs,arachidonoylethanolamide. Since this finding, PEA has been shown to inhibit peripheral inflammation and mast-cell degranulation, as well as to exert neuroprotective and antinociceptive effects in rats and mice. These actions are also mediated by PPAR-α activation and are accompanied by a decrease in neutrophil influx, and expression of proinflammatory proteins such as inducible iNOS and cyclooxygenase-2 (COX-2). In addition to the hypothesis that PEA has potent immunoregulatory properties, recent data have demonstrated that PEA may also play a key role in the regulation of complex systems involved in the inflammatory response, pruritus, neurogenic and neuropathic pain. In this review, we discuss briefly the present understanding therapeutic mechanisms of PEA and the novel possible PEA clinical use for the treatment of several inflammatory diseases and trauma.
We have some kinds of PEA:
1.Palmitoylethanolamide(PEA).
2.Micronized palmitoylethanolamide form (particle dimensions between 6 and 10 microns).
3.Ultramicronized palmitoylethanolamide form (particle dimensions between 0.2 and 5
microns) .
4.Granulating palmitoylethanolamide (PEA).
Storage:Store in cool & dry place, Keep away from strong light and heat.
Shelf Life:2 years if sealed and store away from direct sun light.
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We are a leading manufacturer of herbal extracts and finished health supplement(Vegetarian from HPMC) in China, we have produced many health supplements for many companies in USA and EU since 2005. we ship various kinds of extracts health supplement to our clients in USA, Denmark, Greece, UK, Norway, France, Australia, Hungary....
Regarding our final supplements, your can order:
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Wuxi Gorunjie Natural-Pharma Co.,Ltd.
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Tel: 86-510-8262-0959 Mob: 86-150-5210-9975
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