Tetrahydrobiopterin 99% CAS No. 69056-38-8 (6R) -5, 6, 7, 8-Tetrahydro-L-Biopterin Dihydrochloride Bh4

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Wuhan Golden Wing Industry & Trade Co., Ltd.

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BH4
69056-38-8
C9h17cl2n5o3
C9h17cl2n5o3
Yes
ISO
White
Apis
Keeping Health and Promoting Growth
White to Light Yellow Powder
99.0%Min
2.0%Max
Golden Wing
Fluorinated Bottles
10g/bottle, 100g/bottle
China
2934999090
Product Description
Product Description

Introduction
Tetrahydrobiopterin (BH4, THB), also known as sapropterin (INN), is a cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide syntheses.Chemically, its structure is that of a (dihydropteridine reductase) reduced pteridine derivative (Quinonoid dihydrobiopterin).

Medical use
Tetrahydrobiopterin is available as a tablet for oral administration in the form of sapropterin dihydrochloride (BH4*2HCL). It was approved for use in the United States as a tablet in December 2007 and as a powder in December 2013. It was approved for use in the European Union in December 2008, Canada in April 2010, and Japan in July 2008. It is sold under the brand names Kuvan and Biopten. The typical cost of treating a patient with Kuvan is US$100,000 per year. BioMarin holds the patent for Kuvan until at least 2024, but Par Pharmaceutical has a right to produce a generic version by 2020.
Sapropterin is indicated in tetrahydrobiopterin deficiency caused by GTP cyclohydrolase I (GTPCH) deficiency, or 6-pyruvoyltetrahydropterin synthase (PTPS) deficiency. Also, BH4*2HCL is FDA approved for use in phenylketonuria (PKU), along with dietary measures. 

Specifications
Product Name: Tetrahydrobiopterin
Appearance: White to Light yellow powder
Smell: Odourless
Solubility: Freely soluble in water 
Loss on drying: 2.0% (w/w) Max.
Assay HPLC: 99.0% min
Total ash: 2.5% (w/w) Max.
Heavy metals: <20 ppm
Purity per
6S-BH4.2HCl: 0.5% Max.
Unknown impurities (single): 0.05%  Max.
Unknown impurities (total): 0.1%  Max.
Impurities: 1.0%Max.

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1. Top quality materials with competitive price;
2. Large capacity of stable materials supply;
3. Safety and fast shipment by express/air/sea;
4. Sample order acceptable;
5. Professional and great packing as customized;
6. Convenient payment terms by T/T, Credit Card and online order;
7. Reply inquiries in time

FAQ

Q: Who are you?
A: We are a professional and with more than 20 years experienced supplier and exporter for Industrial & fine chemicals, APIs, Reagent & Lab Supplies, and Food & Food Additives in China.

Q: How can you guarantee quality? 
A: We could provide pre-production sample before mass production. And we also accept the final inspection(third-party) before shipment.

Q: Do you supply free samples?
A: Generally, we could provide free sample for quality evaluation, but the international shipping cost should be undertook by customers.

Q: Which payment terms do you accept?
A: We could accept the payment through T/T, L/C and Online payment.

Q: Can I pay with a credit card
A: Yes, you could feel free to make your payment through credit card. Please contact us for more details

 

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