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Quercetin, widely distributed in fruits and vegetables, is a flavonoid known for its antioxidant, antiviral, antimicrobial, and antiinflammatory properties
Quercetin is the major representative of the flavonoid subclass of flavonols. Quercetin is ubiquitously present in fruits and vegetables, being one of the most common dietary flavonols in the western diet. The anti-cancer effects of quercetin include its ability to promote the loss of cell viability, apoptosis and autophagy through the modulation of PI3K/Akt/mTOR, Wnt/-catenin, and MAPK/ERK1/2 pathways
Quercetin may serve as a potential bioactive substance for atopic dermatitis-related symptoms through anti-inflammatory and antioxidant activities along with its acceleration of wound healing via ERK1/2 MAPK and NF-κB pathways.
Quercetin and its derivatives have shown an array of pharmacological activities in preclinical tests against various illnesses and ailments. Owing to its protective role against oxidative stress and neuroinflammation, quercetin is a possible therapeutic choice for the treatment of neurological disorders. Quercetin and its derivatives can modulate a variety of signal transductions, including neuroreceptor, neuroinflammatory receptor, and redox signaling events. The research on quercetin and its derivatives in neurology-related illnesses mainly focused on the targets, such as redox stress, neuroinflammation, and signaling pathways
* The statements in this section have not been evaluated by the FDA or EFSA.
References
1. Agrawal K, Chakraborty P, Dewanjee S, et al. Neuropharmacological interventions of quercetin and its derivatives in neurological and psychological disorders. Neurosci Biobehav Rev. 2023;144:104955. doi:10.1016/j.neubiorev.2022.104955
2. Beken, Burcin et al. "Quercetin Improves Inflammation, Oxidative Stress, and Impaired Wound Healing in Atopic Dermatitis Model of Human Keratinocytes." Pediatric allergy, immunology, and pulmonology vol. 33,2 (2020): 69-79. doi:10.1089/ped.2019.1137
3. Dabeek, Wijdan M, and Melissa Ventura Marra. "Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans." Nutrients vol. 11,10 2288. 25 Sep. 2019, doi:10.3390/nu11102288
4. Polerà, Nicoletta et al. "Quercetin and its Natural Sources in Wound Healing Management." Current medicinal chemistry vol. 26,31 (2019): 5825-5848. doi:10.2174/0929867325666180713150626
5. Di Petrillo, Amalia et al. "Quercetin and its derivates as antiviral potentials: A comprehensive review." Phytotherapy research : PTR vol. 36,1 (2022): 266-278. doi:10.1002/ptr.7309
