Veterinary Medicine Ivermectin Tablets for Insect Repellent Use in Pigs and Sheep

Character This product is a white tablet.

Pharmacological effects: Ivermectin mainly has a good repellent effect on nematodes and surface arthropods in vivo. The mechanism of its insect repellent effect is to promote the release of presynaptic neurons γ- Aminobutyric acid (GABA) opens the GABA mediated chloride ion channel.
Ivermectin also has selectivity and high affinity for glutamate mediated chloride ion channels located near GABA mediated sites in invertebrate nerve and muscle cells, thereby interfering with signal transmission between nerves and muscles, causing the worm to relax and paralyze, leading to death or expulsion from the body. The inhibitory interneuron and excitatory motoneurons of nematodes are their action sites, while the action sites of arthropods are neuromuscular junctions. The removal rate of sheep's blood spearhead nematodes, Ostrich nematodes, Cooper's nematodes, Trichostrongylus (including Eisenhower's nematode), circular nematodes, mouth nematodes, fine necked nematodes, Trichostrongylus, esophagostomus nematodes, reticulum nematodes, as well as adult and fourth stage larvae of sheep's Charlotte nematode, is 97% to 100%. It is also very effective for arthropods, such as fly maggots, mites, and lice. The therapeutic effect on chewing lice and sheep tick flies is slightly poor. Ivermectin is also extremely effective against ticks and flies that reproduce in feces. Although the drug cannot immediately cause tick death, it can affect feeding, molting, and egg laying, thereby reducing reproductive ability. The effect on blood flies is similar. The eradication rate of roundworm, red roundworm, Ranunculus, trichomonas, esophageal nematode, posterior roundworm, coronavirus, and immature nematodes in pigs reaches 94% to 100%. It is also highly effective against intestinal trichinella spiralis (not effective against muscular trichinella spiralis) and has good control effects on pig blood lice and pig scabies. Not effective against flukes and tapeworms.

The pharmacokinetics of ivermectin varies significantly due to differences in animal species, dosage forms, and delivery routes. The bioavailability of subcutaneous injection is higher than that of oral administration, but the absorption of oral administration is faster than that of subcutaneous injection. After absorption, it can be well distributed to most tissues, but it is not easy to enter the cerebrospinal fluid. The apparent distribution volumes of sheep and pigs are 4.6 L/kg and 4 L/kg, respectively. In most animals, the half-life is longer, with sheep and pigs ranging from 2 to 7 days and 0.5 days, respectively. This product is metabolized in the liver, mainly hydroxylated in sheep, and methylated in pigs. Mainly excreted from feces, less than 5% is excreted from urine in its original form or metabolites. Up to 5% of the dosage is excreted from the milk of lactating cows.

Drug interactions: When used together with ethazine, serious or fatal encephalopathy may occur.

Function and Use Macrolide type antiparasitic drugs. Used to prevent nematode diseases, mite diseases, and parasitic insect diseases in sheep and pigs.

Usage and Dosage Oral administration: once, 0.4 tablets per 10kg body weight for sheep; Pig 0.6 pieces.

[Adverse reactions] No adverse reactions have been observed when used according to the prescribed dosage and usage.

Precautions

(1) Prohibited during lactation period.

(2) Curly dogs are prohibited.

(3) Ivermectin is highly toxic to shrimp, fish, and aquatic organisms. The packaging and containers of residual drugs should not contaminate water sources.

(4) Sows should be used with caution for the first 45 days of pregnancy.

[Off medication period]

35 days for sheep and 28 days for pigs.

Specification 5mg

Packaging 100 pieces/bottle.

Storage Keep out of light, sealed, and stored in a dry place.