Factory Supply High Quality Clascoterone CAS 19608-29-8 for Anti-Hair Loss

Product Name: Clascoterone
Chemical Name: 17alpha-Propio17-(1-oxopropoxy)pregn-4-ene-3,20-dione
CAS Number: 19608-29-8
Appearance: White Powder
Purity: 99%

Product Description:

Clascoterone, also known as Cortexolone 17α-propionate or CB-03-01, is a highly selective topical and peripheral androgen receptor (AR) antagonist. It is widely researched for its potential in treating androgen-driven skin conditions such as acne vulgaris.

Applications:

1. Dermatology Research:

   • Effective as a topical antiandrogen for treating acne vulgaris.
   • Used in studies on androgen receptor signaling inhibition.

2. Pharmaceutical Intermediates:

   • Functions as an organic synthesis and medicinal chemistry intermediate.

Mechanism of Action:

Clascoterone binds selectively to androgen receptors (AR) in the skin, blocking androgen-mediated signaling pathways that drive conditions like acne. Its localized action minimizes systemic side effects while maximizing efficacy in the targeted area.

In Vivo Studies:

• In clinical trials, Clascoterone 1% cream was well tolerated and demonstrated significant efficacy compared to placebo:
  • Improved TLC (Total Lesion Count) (P=0.0017).
  • Enhanced ILC (Inflammatory Lesion Count) (P=0.0134).
  • Reduced ASI (Acne Severity Index) (P=0.0090).
• Showed a faster onset of improvement and higher clinical efficacy compared to other treatments.

Key Features:

• Highly Selective: Targets androgen receptors with minimal systemic absorption.
• Efficacy: Clinically proven to reduce acne lesions and severity.
• Topical Application: Offers localized action with fewer side effects.

Storage Information:

• Store at -20°C in a sealed container. Protect from moisture and light to maintain stability.

Use Cases:

• Signal transduction pathway studies involving androgen receptors.
• Development of topical treatments for androgen-related skin conditions like acne vulgaris.

This product is intended for research purposes only and is not for human or veterinary use. For additional details or bulk inquiries, please contact us.