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Sonwu Supply Inhibitor Ibrutinib Pharmaceutical Intermediate Ibrutinib

Price $21.00
Min Order 100 gram
Availability In Stock
Shipping From Shaanxi, China
Popularity 548 people viewed
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Model NO.:
SWP-BX528
Powder:
Yes
Customized:
Customized
Certification:
GMP, HSE, ISO 9001, USP, BP, SGS
Suitable for:
Adult
State:
Powder
Purity:
>99%
Name:
Ibrutinib
Appearance:
White Powder
CAS:
936563-96-1
Mf:
C25h24n6o2
MW:
440.50
MOQ:
100g
Test Method:
HPLC
Sample:
Available
Grade:
Pharmaceutical Grade
Shelf Life:
2 Years
Storage:
Cool and Dry Place
Trademark:
Sonwu
Transport Package:
Vacuum Sealed Foil Bag
Specification:
100g/bag
Origin:
Shaanxi, China
Product Description

 

Product Description
Product NameIbrutinib
CAS936563-96-1
FormulaC25h24n6o2
MW440.50
Purity99%
AppearanceWhite powder
Shelf life2 years
StorageCool and dry place
Ibrutinib is a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm)
Certifications
Application
Ibrutinib is a kind of Bruton tyrosine kinase (BTK) inhibitor, it could be used for the chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). MCL and CLL are belonged to the B-cell non-Hodgkin's lymphoma, which is difficult to easy to recurrent. Common chemical immunotherapy does not have the targeting, often occurs 3 or 4 adverse reactions. Ibrutinib and B lymphocytes could target with BTK which is necessary for formation, differentiation, and transmission of information, inhibit BTK activity irreversibly, and inhibit cell proliferation and survival effectively. Ibrutinib could be rapidly absorbed after oral administration, during 1~2h reach maximum blood concentration, adverse reactions belong to one or two, therefore, Ibrutinib will become a new choice for the CLL and MCL.
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FAQ
1. Customs clearance
1) By Express:
Normally there is no specical need for the recipient to clear the customs. If the customs has an objection,our rich experienced and professional group will help you clear the customs.
2) By Air and by Sea:
Our company will cooperate with the recipient to provide relevant file and information in the customs clearance procedure.
2. Payment
T/T,Western Union,MoneyGram,Trade Assurance Order,L/C etc. 
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