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Poly(lactic-co-glycolic acid) is a copolymer which is used in a host of Food and Drug Administration approved therapeutic devices, owing to its biodegradability and biocompatibility. PLGA are currently widely used in many fields, such as bone nail; coatings; lifting thread; absorbable suture; microspheres, gel for drug delivery etc.
PLGA5050:
•Composition: This copolymer has a 50:50 ratio of lactide to glycolide monomers.
•Degradation: Due to its high glycolide content, PLGA5050 degrades relatively quickly compared to other ratios. The higher glycolide proportion accelerates hydrolysis, leading to faster erosion times.
•Mechanical Strength: It tends to have lower mechanical strength because of its faster degradation rate. This can limit its use in applications requiring long-term structural integrity.
•Applications: PLGA5050 is often used in applications where rapid degradation is desired, such as short-term drug delivery systems, temporary implants, or scaffolds for tissue engineering that need to be replaced by natural tissue rapidly.
PLGA7525:
•Composition: With a 75:25 ratio, this copolymer has a higher percentage of lactide, contributing to its distinct properties.
•Degradation: PLGA7525 degrades more slowly than PLGA5050, providing a more controlled release profile over a longer period. The higher lactide content results in a more crystalline structure, slowing down the degradation process.
•Mechanical Strength: It possesses greater mechanical strength and durability due to its higher lactide content, making it suitable for applications that require support or longer-term implantation.
•Applications: Its properties make it ideal for extended-release drug delivery systems, implants that need to maintain their structure for a moderate duration, and as a scaffold material in tissue engineering where a balance between degradation and mechanical support is crucial.
| Description | Poly(lactic-co-glycolic acid) is a copolymer that is used in a host of Food and Drug Administration-approved therapeutic devices, owing to its biodegradability and biocompatibility. PLGA is currently widely used in many fields, such as bone nails; coatings; lifting thread; absorbable sutures; microspheres, gel for drug delivery, etc. | ||||||
| Physical-chemical properties | Molecular formula (C6H8O4*C4H4O4)n Chemical name Poly(L-lactide-co-glycolide) CAS Registry number 30846-39-0 | ||||||
| Parameter | Item | Test Method | Specification | ||||
| Appearance | Visual | White, pale yellow powder or floccule | |||||
| Inherent viscosity | Ubbelohde viscometer | 0.20-2.50 dl/g | |||||
| Residual Solvent | Gas Chromatography | ≤0.5% | |||||
| Heavy Metal Sulphated Ash | Chemical Reagent Sulfuric Acid | ≤10 ppm ≤0.1% | |||||
| For each batch a certificate of analysis is provided, showing the analytical data determined in our quality control laboratory. Additional analytical data can be made upon request. | |||||||
| Packaging | 100g/500g/1Kg per aluminum foil bag | ||||||
| Recommend storage | Stored in a cool and dry place without sunlight, a refrigerator is recommended. Temperatures (2-8°C) Notice: PLGA with intrinsic viscosity below 0.3 is powdered and will melt at 18-22 °C. | ||||||
| Shelf life | When stored in the original packaging at low temperatures (2-8°C), PLGA keeps its initial properties for at least two years. | ||||||
| Product catalogue | Model | L-LA/GA Ratio | IV | L-LA/GA Proportional Range | IV Range dl/g | ||
| PLG85-03 | 85/15 | 0.3 | 82/18-88/12 | 0.20-0.40 | |||
| PLG85-05 | 85/15 | 0.5 | 82/18-88/12 | 0.40-0.70 | |||
| PLG85-08 | 85/15 | 0.8 | 82/18-88/12 | 0.70-1.00 | |||
| PLG85-12 | 85/15 | 1.2 | 82/18-88/12 | 1.00-1.40 | |||
| PLG85-16 | 85/15 | 1.6 | 82/18-88/12 | 1.40-1.80 | |||
| PLG85-20 | 85/15 | 2.0 | 82/18-88/12 | 1.80-2.50 | |||
| PLG75-03 | 75/25 | 0.3 | 72/28-78/22 | 0.20-0.40 | |||
| PLG75-05 | 75/25 | 0.5 | 72/28-78/22 | 0.40-0.70 | |||
| PLG75-08 | 75/25 | 0.8 | 72/28-78/22 | 0.70-1.00 | |||
| PLG75-12 | 75/25 | 1.2 | 72/28-78/22 | 1.00-1.40 | |||
| PLG75-16 | 75/25 | 1.6 | 72/28-78/22 | 1.40-1.80 | |||
| PLG75-20 | 75/25 | 2.0 | 72/28-78/22 | 1.80-2.50 | |||
| PLG50-03 | 50/50 | 0.3 | 47/53-53/47 | 0.20-0.40 | |||
We offer medical-grade materials:
CAS: 33135-50-1, Poly l-lactic acid(PLLA), PLLA microspheres,CAS: 106989-11-1, Poly d-lactic acid(PDLA), PDLA microspheres,
CAS: 51063-13-9, Poly dl-lactic acid(PDLLA), PDLLA microspheres,
CAS: 24980-41-4, Poly caprolactone(PCL), PCL microspheres,
CAS: 30846-39-0, Poly(L-lactide-co-glycolide)(PLGA), PLGA microspheres,
CAS: 26780-50-7, Poly(DL-lactide-co-glycolide) (PDLGA), PDLGA microspheres, etc.
We have own factory.
The materials come from the original manufacturer in China.
The product quality is very good.
Shipping via DHL or FedEx will be quick and secure.
