Dihexa (PNB-0408), an oligopeptide reagent, is an angiotensin IV analog with oral activity and permeability of the blood-brain barrier. Dihexa binds to Hepatocyte Chemicalbook Growth Facto with high affinity, with a Kd value of 65pM, and enhances its activity on the receptor c-Met. Dihexa has shown excellent antipsychotic activity and improved cognitive function in animal models.
Product Name | Dihexa |
CAS | 1401708-83-5 |
Appearance | White powder |
MF | C27H44N4O5 |
Molecular Weight | 504.66 |
Purity | 99% min |
Storage | Keep in a cool, dry, dark location in a tightly sealed container or cylinder |
Shelf Life | 24 Months |


Items | Standard | Results | |||
Characters | white powder | Qualified | |||
Identification | Meets the requirements | Qualified | |||
Appearance of solution | Meets the requirements | Qualified | |||
Organic volatile impurities | Meets the requirements | Qualified | |||
Heavy metals | ≤0.002% | Qualified | |||
Loss on drying | ≤0.5% | 0.10% | |||
Residue on ignition | ≤0.1% | 0.02% | |||
Assay | 98.0% ~ 102.0% | 99.8% | |||
CONCLUSION: | This is certify that the product complies to the standards |

Dihexa dramatically improves cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
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