Audited Supplier
NY007
ISO, Halal
HPLC-MS, HPLC
Tablet, Capsule
Health Care Products, Medicine
Powder
Magnolia Officinalis
5 Days
Nutrayours/ OEM
Paper Drum
98%
China
1302199099
Product Description
- 100% NATURAL PRODUCT: No artificial colors or flavors
- Verified herb identity, confirmed highest quality of raw herb and the extract
- Best natural sources of herbs and raw materials: Every vendor is carefully picked to meet our high standards
- Third-party lab tested, pure Honokiol.
Honokiol, a biologically active substance extracted from Magnolia officinalis, which is widely used in traditional Chinese medicine, has been shown to exert significant anti-inflammatory effects and improve depression-like behavior caused by inflammation.
Honokiol ameliorated LPS-induced NF-κB activation in the hippocampus and significantly reduced the levels of the pro-inflammatory cytokines; tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interferon γ (IFN-γ). In addition, honokiol inhibited LPS-induced indoleamine 2,3-dioxygenase (IDO) activation and quinolinic acid (a toxic product) increase and reduced the level of free calcium in brain tissue, thereby inhibiting calcium overload.
| Contaminants | |||
| Arsenic (As) | ≤ 0.1 mg/kg | <0.005 | GB 5009.76 |
| Lead (Pb) | ≤ 0.1 mg/kg | <0.050 | GB 5009.75 |
| Mercury (Hg) | ≤ 0.1 mg/kg | <0.003 | GB 5009.17 |
| Cadmium(Cd) | ≤ 0.1 mg/kg | <0.005 | GB 5009.15 |
| Microbiological | |||
| Total Plate Count | ≤ 1,000 cfu/g | <10 cfu/g | GB 4789.2 |
| Mold&Yeast | ≤ 100 cfu/g | <10 cfu/g | GB 4789.15 |
| E. Coli | <10 cfu/g | <10 cfu/g | GB 4789.3 |
| Salmonella | Absent/25g | Not Detected | GB 4789.4 |
| Staphylococcus aureus | <10 cfu/g | <10 cfu/g | GB 4789.10 |
* The statements in this section have not been evaluated by the FDA or EFSA.
References
1. Borgonetti V, Galeotti N. Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain. Antioxidants (Basel). 2023 Jul 28;12(8):1518. doi: 10.3390/antiox12081518. PMID: 37627513; PMCID: PMC10451803.
2. Zhang B, Wang PP, Hu KL, et al. Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model. Molecules. 2019;24(11):2035. Published 2019 May 28. doi:10.3390/molecules24112035
3. Borgonetti V, Galeotti N. Honokiol-Rich Magnolia officinalis Bark Extract Attenuates Trauma-Induced Neuropathic Pain. Antioxidants (Basel). 2023 Jul 28;12(8):1518. doi: 10.3390/antiox12081518. PMID: 37627513; PMCID: PMC10451803.
